In this large cohort of 452 younger adult AML patients, we could confirm that ~30% of FLT3-ITDs are localized outside the JMD with a major cluster in the beta1-sheet of the TKD1 (28%), and at very low frequencies (≤1%) in the nucleotide-binding loop, the beta2-sheet of the TKD1, and 3 ́ of the beta2-sheet [12, 13]. The gene discussed is FLT3; the disease is acute myeloid leukemia.