The inflammation biomarkers based on CRP (C Reactive Protein) or ALB (Albumin) or lymphocyte level, such as GPS (Glasgow Prognostic Score), CAR (C Reactive Protein to Albumin Ratio) and CLR (C Reactive Protein to Lymphocyte Ratio) etc. are closely related to the prognosis in a variety of cancers including esophageal cancer10–13. This evidence concerns the gene CRP and cancer.