Besides, myofibrillar structural protein myomesin-3 (MYOM3) was not only associated with muscular dystrophy related proteins and muscle strength, which could be a potential biomarker for monitoring of muscular dystrophy, but was hypermethylated in ischemic cardiomyopathy (ICM)41,42. This evidence concerns the gene PROS1 and ischemic cardiomyopathy.