STING1 and neoplasm: Notably, while we demonstrate that STING-mediated IFN-I signaling exerts direct effects on pain via direct suppression of nociceptor excitability (neuromodulation), the potent analgesic effects of STING agonists in vivo are likely owed to a combinatorial suppression of tumor burden and bone destruction (immune modulation), and direct effects on nociceptive sensory neurons.