STING1 and bone neoplasm: To further observe the protective effect of STING agonist on bone cancer pain, we used a more physiological model of bone metastasis by administering LLC cells (200,000 in 100 μl) via intra-caudal artery injection (Supplementary Fig. 8a), which was recently reported to deliver cancer cells to the hind limbs and caudal vertebrae with high efficacy and cause bone destruction46.