To test whether STING agonist-induced reduction in tumor burden is due to T cell-mediated antitumor immunity, we introduced LLC cells into the intrafemoral cavity of WT or Rag1−/− mice lacking mature B and T cells, followed by vehicle or DMXAA treatment (20 mg/kg i.p. at d3 and d7 post-inoculation) and measurement of maximum thigh circumference at d17 as in Fig. 6b. The gene discussed is STING1; the disease is neoplasm.