Since the natural activators of STING are intracellular double-stranded DNA (dsDNA), via a cGAS-dependent pathway, and via a cGAS-independent pathway involving bacterially-derived cyclic dinucleotides such as 3′3′-cGAMP41, we also assessed whether dsDNA and 3′3′-cGAMP could produce antinociception in the bone cancer model. The gene discussed is CGAS; the disease is bone neoplasm.