DNMT3A and myeloid neoplasm: Mouse models have further established the risk of developing hematopoietic malignancies: Dnmt3a deficiency is associated with the development of myeloid, erythroid, B-, and T-cell malignances32,44–50 and Dnmt3a haploinsufficiency in the germline is associated with the development of myeloid malignancies after a long latent period30.