Although we do not suggest that dysregulation of these specific genes is directly relevant for the DOS phenotype, it is interesting to note that HOXB cluster genes have been found to be downregulated in children with autism spectrum disorders40, and that the RASIP1 locus has been found to be hypomethylated in the blood of children with the Floating Harbor Syndrome41, which is caused by pathogenic variants in SRCAP, and associated with facial dysmorphology and learning disabilities (MIM #136140). This evidence concerns the gene RASIP1 and learning disability.