The accumulation of cellular senescence markers such as p16, SA-β-gal, and the lack of the proliferation marker Ki67 was detected also in skin and meninges histiocytic lesions from patients affected by BRAFV600E-mutated Erdheim-Chester histiocytosis (Fig. 5e and Supplementary Fig. 7c). Here, CDKN2A is linked to Erdheim-Chester disease.