Treatment with MK-2206 (AKT 1/2/3 inhibitor), Stattic (STAT3 inhibitor), Ruxolitinib (JAK1/2 inhibitor), or Sotrastaurin (pan-PKC inhibitor) did not induce the jamming transition in distal IPF epithelia (Supplementary Fig. 7B, C). Here, STAT3 is linked to idiopathic pulmonary fibrosis.