ESCO2 and retinoblastoma: In unsupervised methylation analysis, the O-PDXs and iPSC-RBs overlapped with retinoblastomas/pineal tumors from a reference collection of 2901 brain tumor methylation profiles29 and they were clearly separated from the normal retinal organoids and iPSCs in tSNE plots (Fig. 4H–K and Supplementary Data 5).