Mendelian disorders of SLC30A10 and the other hepatic Mn transporter genes SLC39A8 (solute carrier family 39 member 8, causing congenital disorder of glycosylation type IIn)74 and SLC39A14 (solute carrier family 39 member 14, implicated in hypermanganesemia with dystonia 2)75, along with experiments in transgenic mice76,77, have confirmed the critical role of each of these genes in maintaining whole-body manganese homeostasis78. Here, SLC30A10 is linked to SLC39A8-CDG.