SLC30A10 and liver disorder: Liver disease is found more frequently in our sample of carriers of SLC30A10 Thr95Ile (rs188273166), proportional with the observation of increased ALT and AST (OR = 1.47); however, owing to the small sample size of carriers and liver disease cases, we are underpowered to confidently determine whether this high point estimate is due to chance (although the 95% CI from the PLINK analysis used to estimate effects does not include OR = 0, the p value from the SAIGE analysis which more accurately controls for Type I error in highly unbalanced case-control studies is 0.07; see “Methods”).