SLC39A8 and toxic encephalopathy: Neurotoxicity is an aspect of the Mendelian syndromes caused by loss of function of all three of the hepatic manganese transporters; interestingly, GWAS has also identified a common missense variant in SLC39A8 as a risk factor for schizophrenia and many other diseases88,89; altered function of glycosyltransferases due to manganese overload in the neurons is a proposed mechanism for neurological manifestations of this variant90.