SLC30A10 and extrahepatic bile duct carcinoma: To test whether the association with extrahepatic bile duct cancer was driven by a nearby association, and to assess other risk variants and the potential for false positives given the extreme case-control imbalance, we performed a GWAS of the phenotype; remarkably, SLC30A10 Thr95Ile was the strongest association genome-wide, with minimal evidence for systematic inflation of p-values (λGC = 1.05; Fig. 5, Supplementary Fig. 5).