Moreover, a significant correlation was observed in KPC (KrasLSL-G12D; Trp53LSL-R172H; Pdx1-Cre) and KTC (KrasLSL-G12D/+; Tgfbr2flox/wt; Ptf1a-Cre) autochthonous pancreatic tumors in a genetically engineered mouse model (GEMM) (Supplementary Fig. 6c–e). Here, PTF1A is linked to pancreatic neoplasm.