Reasoning that RSL3 and erastin trigger ferroptosis by targeting GPX4 and system XC−, respectively, through which finally reduce utilization or production of glutathione (GSH), we thereby tested whether TRIB2/βTrCP/TFRC axis affects sensitivity of liver cancer cells to ferroptosis that induced by RSL3 and erastin via modulating GSH levels. This evidence concerns the gene TRIB2 and liver cancer.