To investigate whether TRIB2 desensitizes liver cancer cells to ferroptosis, a serial of liver cancer cell lines including Bel-7404, Bel-7402, SMMC-7721, SK-Hep1, and HepG2 cells were tested for their sensitivity to RSL3 and erastin, two well-established ferroptosis agonists. The gene discussed is TRIB2; the disease is liver cancer.