Due to the fact that TRIB2 decreases the degree that labile iron is elevated upon ferroptosis, we speculate that ferritinophay is a prerequisite to provide labile iron for the induction of ferroptosis, while TRIB2 and βTrCP-mediated ubiquitination and followed degradation of TFRC determines the sensitivities of liver cancer cells to ferroptosis. The gene discussed is TFRC; the disease is liver cancer.