PRF1 and colonic neoplasm: As displayed Figure 11A–11H, the expression of genes related to ICIs was positively correlated with the autophagy-related risk score and increased in the high-risk score patients with colon cancer (P < 0.05), such as PDCD1, HAVCR2, CTLA4, CD8A, CXCL9, LAG3, TBX2, and PRF1. The results above suggest that the high-risk score patients are more sensitive to immunotherapy.