We identified 6 prognostic-related ARGs (ULK3, ATG101, MAP1LC3C, TSC1, DAPK1 and SERPINA1) to formulate a novel autophagy-related signature, which could stably predict the survival of patients and indicate the extent of immunosuppressive microenvironment in colon cancer. Here, TSC1 is linked to malignant colon neoplasm.