To investigate the role of neuronal FT in the pathogenic process of AD, FTf/f Cre+ mice were crossed with APP/PS1/FTf/f to produce APP/PS1 mice with neuronal FT knockout (APP/PS1/FTf/f/Cre+ , designated as APP/PS1/FTnKO), and littermate APP/PS1 controls (APP/PS1/FTf/f/Cre-, designated as APP/PS1), along with FTf/f/Cre+ (FTnKO) and FTf/f/Cre- (wild-type, WT) mice. The gene discussed is PSEN1; the disease is Alzheimer disease.