Similarly, by establishing HCC sorafenib-resistant (SR) cell lines (HepG2-SR, SKhep1-SR, Huh7-SR and LM3-SR cells), Xu et al. found that METTL3 and METTL14 increase the stability of circRNA-SORE, which sequesters miR-103a-2-5p and miR-660-3p by acting as a microRNA sponge, thereby competitively activating the Wnt/β-catenin pathway and inducing sorafenib resistance [42]. The gene discussed is METTL3; the disease is hepatocellular carcinoma.