PIK3CA and cancer: Within the past few years, extensive studies have suggested the pivotal role of m6A methyltransferases in cancer [16], and the crucial roles of m6A methyltransferases in regulating several key pathways have been reported, including MYC, Wnt/β-catenin, PI3K/AKT/mTOR, p53, BCL-2, and FOXO-SOX, which drive the cancer phenotype.