METTL3 and neoplasm: However, we also need to emphasize that the context-dependent functions of m6A methyltransferases in cancer resistance, such as the opposite roles of METTL3 and METTL14 in sorafenib resistance, and related factors (e.g., genetic/epigenetic heterogeneities of cancer cell lines and primary tumor specimens) that affect the functions of m6A methyltransferase in a given targeted therapy need to be better understood.