In the stratified analysis, Q4 of Lp(a) had a significantly lower T2DM risk in men [0.813 (0.734, 0.900), P < 0.001] (Fig. 2A) and the elderly population aged > 60 years [0.819 (0.737, 0.910), P < 0.001] (Fig. 2D). This evidence concerns the gene LPA and type 2 diabetes mellitus.