Although Zhang et al. identified key candidate genes and constructed novel miRNA–mRNA regulatory axes in CRC liver metastasis, and found that miR-885 promoted CRC cell migration by decreasing the expression of von Willebrand factor (vWF) and insulin-like growth factor binding protein 5 (IGFBP5) by using integrated bioinformatics analysis and in vitro experiments [19], studies identifying biomarkers associated with CRC metastasis by bioinformatics analysis are scare. This evidence concerns the gene IGFBP5 and colorectal carcinoma.