As shown in Fig. 8E–G, the expression of hsa-miR-99a and hsa-miR-100 decreased significantly in CRC tissue with lymph node metastasis compared to CRC tissue without lymph node metastasis (P < 0.01, P < 0.05), while the expression of HS3ST2 greatly increased in CRC tissue with lymph node metastasis (P < 0.05). Here, HS3ST2 is linked to metastatic malignant neoplasm in the lymph nodes.