The per-allele effect for increasing T2D risk yielded an OR (95% CI’s) of 1.03 (0.97,1.09), P=0.207, and Z score = 0.16 for the GC variant (rs2282679), and 1.01 (0.97,1.05), P=0.453, Z score = 1.09 for the CYP2R1 (rs12794714). However, the per-allele effect of the DHCR7 (rs12785878) variant showed a significantly increased risk for T2D OR 1.05 95% CI (1.0, 1.11), P=0.004, and Z score =2.84 in the meta-analysis (Supplementary Table 4). Here, CYP2R1 is linked to type 2 diabetes mellitus.