[31] also could not capture the impact of genetically regulated 25(OH)D concentration on T2D using a genetically instrumented gene score of four SNPs GC (rs2282679), CYP2R1 (rs10741657), Cyp27A1 (rs6013897) and DHCR7 (rs12785878) with T2D (p = 0.07) in meta-analysis despite using a sample size of up to 476,099 of Chinese and European adults. This evidence concerns the gene CYP2R1 and type 2 diabetes mellitus.