The gene score construction for SNP alleles associated with an increased risk for T2D, IGF2BP2 (rs1470579), TCF7L2 (rs7903146), and KCNQ1 (rs2237896) showed a significant association with increased risk for T2D in all studies OR (95% CI) 1.24 (1.22, 1.26), P= 1.82x10-32, Z score 11.86 in 51,816 subjects (Table 2; Supplementary Figure 1A). This evidence concerns the gene KCNQ1 and type 2 diabetes mellitus.