Dyslipidemia promotes the activation of interleukin 1 (IL-1) dependent pathway by activating nucleotide-binding oligomerization domain-, leucine-rich repeat- and pyrin domain-containing 3 (NLRP3) inflammasome, which is conducive to IL-1 cleavage and secretion, and modifie-LDL via scavenger receptors upregulates interleukin 6 (IL-6) in endothelial cells. The gene discussed is IL6; the disease is metabolic syndrome.