In the univariate linear regression analysis, log-transformed plasma adiponectin levels were positively correlated with frailty severity, log-transformed plasma ZAG levels, and the use of thiazolidinediones (TZDs), while negatively correlated with BMI, waist circumference, ASMI, the co-morbidities of hypertension and hyperlipidemia (Table 2). The gene discussed is ADIPOQ; the disease is hyperlipidemia.