EGFR and non-small cell lung carcinoma: Later, afatinib, a second-generation EGFR TKI, which serves as a pan-human EGFR(HER) family inhibitor that irreversibly binds to EGFR, was approved for the treatment of EGFRm+ NSCLC, based on the results of pivotal randomized clinical studies (LUX-Lung 3, LUX-Lung 6, and LUX-Lung 7) [7–9].