HIF1A and neoplasm: For the tumor size, one network was generated based on the six target genes of miR-519c-3p (Table 3, Fig. 5a); considering their involvement in the biological process (GO), four of these targets were reported as related to negative regulation of growth (PTEN, CDKN1A, HIF1A), of the mitotic cell cycle (PTEN, CDKN1A, TIMP2), and vascular smooth muscle cell proliferation (PTEN, CDKN1A).