Xu et al. developed a novel self-assemblingNIR nanofiber imaging probe for the detection of MMP2 and MMP9 activityin renal cell carcinoma.91 The probe TER-SAconsisted of a NIR cyanine dye conjugated to a large peptide, including(1) a tumor-targeting RGD sequence, (2) a PLGYLG MMP-2/9 cleavablesequence, and (3) a YLGFFC self-assembling motif. Here, MMP2 is linked to hereditary clear cell renal cell carcinoma.