In a similar approach, Kong et al. reported TMN-Leu asprobe where a leucine residue was coupled to a dicyanoisophorone reporterto produce a large increase in emission with LAP activity at 658 nm.38 TMN-Leu showed a detection limit of 0.38 ngmL–1 and was described to image LAP activity invivo in HCT116 tumor-bearing mice. This evidence concerns the gene LAP3 and neoplasm.