The same grouprecently developed a dual NIR-photoacoustic (PA) probe for monitoringthe activity of urokinase-type plasminogen activator (uPA), a serineprotease that has been implicated in breast cancer and metastasisformation.78 In this case, a glycosylatedhemicyanine dye was conjugated to the uPA-specific peptide sequenceCbz-Gly-Gly-Arg via a PABA linker to furnish P-Dex. This evidence concerns the gene PLAU and breast carcinoma.