The expression of CDK5 (Figure 5F), GRIN2β (Figure 5G), GRIN1 (Figure 5H) and GSK3β (Figure 5I) was significantly downregulated but the expression of P2RX7 (Figure 5J), SOAT1 (Figure 5K) and TSPO (Figure 5L) was upregulated in the temporal cortex in AD patients compared to controls. The gene discussed is CDK5; the disease is Alzheimer disease.