In a recent study, Shochet et al. reported in experimental research between IPF patients and normal healthy donors that IL-6 trans-signaling components lead to indirect TGF-β, which is well-known as a pro-fibrotic growth factor with an influence on pathway activation and disease progression, suggesting the importance of IL-6 in IPF pathogenesis [14]. The gene discussed is IL6; the disease is idiopathic pulmonary fibrosis.