SCN1A and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy: We observed similar modifications in experimental traces, comparing cortical layer 2-3 fast spiking GABAergic neurons recorded in heterozygous Scn1a knock-out mice (Scn1a+/-), model of the developmental and epileptic encephalopathy Dravet syndrome [1, 2], and wild type littermates as control (Figs 9C, 9D and 10B).