In another case, the ER-α3+ BCa tumor (4318–1) had the highest mean ER-α46 expression level among ER-α-/+ breast tissue biopsies (μER-α46,4318–1 = 2.24 × 106, nER-α46,4318–1 = 12l cells), yet mean ER-α46 expression level in 4318–1 is 1.6-fold lower than mean ER-α46 expression level of MDA-MB-231 (μ4318–1 = 1.46 × 106, μMDA-MB-231 = 2.56 × 106; n4318-1 = 55 cells, nMDA-MB-231 = 601 cells; Fig 2A). Here, ESR1 is linked to neoplasm.