HYAL2 and COVID-19: We next asked whether plasma from patients with COVID-19 could alter transcription of genes responsible for HA synthesis or degradation and found that treatment with COVID-19 patient plasma significantly increases mRNA expression of HA synthase-3 (HAS3), hyaluronidase-1 (HYAL-1), and HYAL-2 compared with treatment with healthy donor plasma (Figure 4, E and F).