TBX21 and diabetes mellitus: Treatment of BDC mice with αCD3 Ab (clone 2C11), a therapy shown to reverse diabetes in NOD mice, however, decreased expression of Foxo1-axis genes but increased expression of TCR-driven genes (Irf4, Nr4a1, Cd25, Cd69, Tbx21) in PLN BDC CD4+ T cells (Figure 2E).