Significantly higher OPG plasma concentration has been confirmed in patients with CAD compared to healthy volunteers, and in a group of patients diagnosed with CAD, these high concentrations of OPG are associated with a greater range of atherosclerotic lesions in the coronary arteries and a higher risk of death [3, 5, 6, 10–12, 18]. Here, TNFRSF11B is linked to coronary artery disorder.