In studies evaluating a series of patients admitted to hospital with ST-segment elevation myocardial infarction (STEMI) and given percutaneous coronary intervention (PCI), high plasma concentrations of OPG turned out to be an independent predictive factor of death, recurrent myocardial infarction (MI) and hospitalisation for HF, even after taking into account the classic factors of poor prognosis [11, 21]. This evidence concerns the gene TNFRSF11B and myocardial infarction.