Our findings suggested that compared with the healthy control group, the expressions of CEACAM8, CD19, MMP9, ARG1, CKAP4, CCR7, MGAM, CD79B, and CLEC4D in patients with IS were significantly upregulated, which may have an important influence on the pathophysiological mechanism of ischemic stroke. The gene discussed is CLEC4D; the disease is ischemic stroke.