On the basis of the DEMETER2 absolute gene scores, for 3/4 novel missense mutational cancer genes (DDX27, CCNK, RNF40) and 5/5 novel non-missense mutational cancer genes (TTK, GEMIN5, MMS22L, USP7, NOL11), gene knockdown in the wild-type cell lines reduced cell viability while in the mutant cell lines, gene knockdown further reduced cell viability. The gene discussed is TTK; the disease is cancer.