LGR5 and cancer: We identified several well-known oncogenes as tumor-promoting effectors, including CDK1 (breast cancer and lung adenocarcinoma), WEE1 (colorectal cancer), RAC1 (breast cancer), CTNNB1 (colorectal cancer), LGR5 (breast cancer), YAP1 (colorectal cancer) and WWTR1 (kidney cancer), all of which are frequently overexpressed in diverse types of cancers.