NR1H4 and obesity due to melanocortin 4 receptor deficiency: Inhibiting intestinal FXR signaling by treating with antibiotics or tempol can reduce high-fat diet-induced hepatic triglyceride accumulation.124 Modulating gut bacteria to decrease intestinal FXR activation can ameliorate the high-fat diet-induced obesity.122,125 Moreover, DCA-activated intestinal FXR signaling inhibits prostaglandin E2 production and promotes crypt regeneration, which benefits the colonic wound repair.126