In the present study, firstly, we examined YTHDC2 expression in TCGA tumours and found that YTHDC2 was significantly down‐regulated in the majority of cancers than in the normal samples, including ACC, BLCA, BRCA, CESC, COAD, ESCA, KICH, LIHC, LUAD, LUSC, OV, PRAD, READ, SKCM, TGCT, THCA, UCEC and UCS, but was up‐regulated in CHOL, DLBC, KIRC, LGG, PAAD, LAML and THYM. This evidence concerns the gene YTHDC2 and cancer.