BACE1 and Alzheimer disease: We therefore investigated whether APP processing could also be affected in 5XFAD strain of AD mice with reduced AMY/CTR expression and to this end measured total APP, full-length APP, β-secretase 1 (BACE1), and soluble oligomeric fraction of Aβ42 in lysates obtained from hippocampal and cortical tissue from 5XFAD and HetCTR + 5XFAD mice (n = 5 for each group).