CD22 and acute lymphoblastic leukemia: In the cohort with B-ALL, median age was 47 years (range 26–68); 71% had progressed after allogeneic hematopoietic cell transplantation (HCT), 65% had previous CD19-directed therapy (including 1 patient receiving previous CAR T) and 29% had previous CD22-directed therapy (Table 2).