Since the expression of GITR and GITRL in CRL5946 mesothelioma cells can be induced by exposing them to cisplatin or Cs-137 irradiation, we treated CRL5946 cells with 2 μg/mL cisplatin or 7.5 Gy Cs-137 irradiation and then blocked GITR/GITRL-mediated signaling by using N-mAb for 3 days (Fig. 4c). Here, TNFRSF18 is linked to mesothelioma.