IPA disease and functional analysis pointed out that the most significantly enriched diseases and biological function [−log (P value) >1.3, Z-score>2 or <−2] of GITR+ and GITRL+ cells were associated with cancer, upregulated cell-cycle regulation (G2/M phase, S phase of tumor cell lines) and colony formation (only in GITRL+ cells). The gene discussed is TNFSF18; the disease is cancer.