TNFRSF18 and mesothelioma: Moreover, when culturing those isolated subpopulations as a monolayer fashion on plates, the distribution of these three subpopulations returned to normal equilibria demonstrating that there is a stochastic interconversion between GITR−GITRL−, GITR+, and GITRL+ cells contributing to the heterogenicity of CRL5946 mesothelioma cells (Fig. S4).