In enriched KEGG pathway (C2), a great majority of cancer-related pathways were activated in high-risk group, including DNA replication, cell cycle, bladder cancer, and p53 signaling pathway, etc.; while numerous metabolism-associated pathways were suppressed in high-risk group, including β-alanine metabolism, tryptophan metabolism, retinol metabolism, and pyruvate metabolism, etc. (Fig. 5a). Here, TP53 is linked to cancer.