PPARA and prion disease: Overlapping the C5 of GSEA in Supplementary Table S1 and KEGG pathways in Supplementary Table S5, seven mutual pathways were identified including glyoxylate and dicarboxylate metabolism, primary bile acid biosynthesis, complement and coagulation cascades, PPAR signaling pathway, tryptophan metabolism, propanoate metabolism, and prion disease.