In support of an epileptogenic role for Kcna1 mutations, a Kcna1 knock out mouse model (Kcna1−/−) exhibits phenotypes similar to patients with severe epilepsy as characterized by recurrent spontaneous seizures including myoclonic and generalized tonic–clonic seizures beginning at 3–4 weeks postnatally13,14. Here, KCNA1 is linked to epilepsy.