This may be due to low immunity (reduced lymphocyte count)26,27, coagulation disorders (decreased platelet count, prolonged prothrombin time, and increased d-dimer)28,29, poor nutrition (anemia and hypoproteinemia), and persistent inflammatory states (high procalcitonin, interleukin-6, and C-reactive protein)30 in patients with impaired renal function (eGFR < 90 mL/min/1.73 m2). This evidence concerns the gene F2 and blood coagulation disease.