Among the up-regulated proteins in the Sepsis group compared to the Control group, the pathways with the highest statistical significance were related to glycolytic metabolism, including the canonical enzymes PGK1, ALDOA, ALDOC, GADPH, PKLR GPI, as well as LDHA, responsible for converting pyruvate into lactate in situations where oxidative phosphorylation decreases. Here, PKLR is linked to Sepsis.