Studies have pointed out that TRPM7 overexpression and/or activation is involved in growth and proliferation of several cancers (glioma, gastric, oesophageal, lung, breast, ovary, bladder, prostate, retinoblastoma, colon, pancreas, head and neck, nasopharyngeal)17–24 and therapeutic strategies with anti TRPM7 drugs have been designed in cancer patients17,23,24. Here, TRPM7 is linked to retinoblastoma.