To test whether SENP1 knockdown can induce apoptosis in MCL cells, we detected the apoptosis of stable Jeko-1 cells with shSENP1-2 or shSENP1-3 and stable Mino cells with shSENP1-1 or shSENP1-3 by Annexin V-APC and PI double staining. The gene discussed is SENP1; the disease is mantle cell lymphoma.