RB1 and mantle cell lymphoma: We also explored whether SENP1 knockdown can affect the cell cycle of MCL cells by flow cytometric analysis, and the results showed there was no significant difference in cell cycle distribution between stable cells with SENP1 knockdown and control cells (Fig. 2D, E), which was further demonstrated by detecting the expression of cell cycle related proteins, including Rb, p-Rb and CyclinD1 (Fig. 2F, G).