To test the expression of SENP1 in MCL, we firstly detected the expression of SENP1 in human MCL specimens and reactive lymph node enlargement specimens by immunohistochemistry, which showed that the SENP1 protein expression in the MCL specimens was significantly higher than that in the reactive lymph node enlargement specimens (Fig. 1A, B). This evidence concerns the gene SENP1 and mantle cell lymphoma.