In addition to Huh7 and Hep3B cells, we analyzed the HCC cell lines HepG2 and HLF and observed similar NOXA, BCL-XL, and MCL-1 expression and comparable cell death induction by sorafenib and TRAIL as in Huh7 cells (Supplemental Fig. 1A−C). This evidence concerns the gene PMAIP1 and hepatocellular carcinoma.