Inflammatory genes, such as interleukin-1 beta (IL-1β), IL-8, leukemia inhibitory factor (LIF), NOS2, and prostaglandin-endoperoxide synthase 2 (PTGS2), are over-expressed in granulosa cells (GCs) of PCOS patients, indicating inflammation of the ovarian GC responses [60]. The gene discussed is LIF; the disease is polycystic ovary syndrome.