Additionally, there were significant differences between T1DM and normal samples that TLR3, HLA-DQA1 and CCR3 were only related to CD8+ T cells (P < 0.05), resting mast cells (P < 0.05) and Neutrophils (P < 0.05), respectively. The gene discussed is HLA-DQA1; the disease is type 1 diabetes mellitus.