VMP1 and central nervous system cancer: In this study, we aimed to (i) explore the associations of VMP1 expression with clinicopathologic features in glioma, (ii) evaluate its prognostic value, (iii) elucidate the biological functions and underlying signaling pathways of VMP1 in the development and progression of glioma, and (iv) determine the role of VMP1 in modulating glioma autophagy.