PAPOLG and dental caries: Another suggestive association signal at 2p16.1 (rs11686767, P = 3.11 × 10−8), is intronic to PAPOLG (Fig. 2d) which plays a role in catalyzing template-independent extension of a DNA/RNA strand [36] The SNP is a strong eQTL for PAPOLG [16], however, no known role yet of this gene in odontogenesis or dental caries.