TAS2R4 and dental caries: An interesting suggestive association for the permanent dentition DFT was at 7q34 (lead SNP rs11197981; P = 1.11 × 10−6), approximately 200 kb downstream of taste receptor genes (TAS2R38, TAS2R3, TAS2R4, TASR25) (Fig. 2e), which have plausible roles in dental caries.