In further investigation, the KEGG enrichment analysis-based findings revealed all calycosin-anti-BPA-related OS mechanisms, including IL-17 signaling pathway, Th17 cell differentiation, Endocrine resistance, Estrogen signaling pathway, Proteoglycans in cancer, MicroRNAs in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, VEGF signaling pathway, GnRH signaling pathway, PI3K-Akt signaling pathway, TNF signaling pathway, FoxO signaling pathway. This evidence concerns the gene AKT1 and cancer.