Combined with previous results shown that pMGF505-7R strongly inhibited NF-κB activation (Fig 4B) and ASFV-Δ7R infection induced much higher levels of IL-1β mRNA transcription compared with ASFV-WT (Fig 5A), our results suggest that ASFV-Δ7R induces IL-1β production through TLRs signaling pathway and pMGF505-7R functions to block the “first signaling” of inflammatory responses. Here, IL1B is linked to infection.