To determine the role of Lum in AD, we subjected Lum−/− and WT mice to a BAPN (1 g/kg/day of 3-aminopropionitrile fumarate salt metabolite) diet for 4 weeks and then implanted a minipump for Ang II (1 μg/kg/min) challenge for another 4 weeks. Here, AGT is linked to Alzheimer disease.